DIFFERENTIAL EXPRESSION OF ENZYMES IN THYMIDYLATE BIOSYNTHESIS IN ZEBRAFISH AT DIFFERENT DEVELOPMENTAL STAGES: IMPLICATIONS FOR DTYMK MUTATION-CAUSED NEURODEGENERATIVE DISORDERS

Abstract Background Deoxythymidine triphosphate (dTTP) is an essential building block of DNA, and defects in enzymes involved in dTTP synthesis cause neurodegenerative disorders.For instance, mutations in DTYMK, the gene coding for thymidylate kinase (TMPK), cause severe microcephaly in human.However, the mechanism behind this is not well-understoo

The ability to communicate is a prerequisite of the process of building interpersonal relationships, of social integration.Communication is a complex process involving the exchange of Wooden Dolls messages between at least two people and implies a harmonious combination of verbal, paraverbal and non-verbal language.Communication skills are particul

During the 19th and the beginning of the 20th century Osijek was one of the most important towns in Croatia.Some parts of its economic life even gave it a distinguished place in the Austro-Hungarian Monarchy.In the middle of the 19th century Croatia went from the old feudal judicial Wooden Toy system to a new system in which administration, at leas

The capability to orient the solar arrays of a spacecraft toward the Sun Puzzle is an ultimate asset for any attitude determination and control subsystem (ADCS).This ability should be maintained in any operative circumstance, either nominal or off-nominal, to avoid the loss of the entire space-borne system.The safe mode implementation should guaran

Abstract The COVID-19 pandemic has increased germ aversion, an aversive affective response to a high likelihood skateboards of pathogen transmission.While psychological factors are associated with chronic pain, the relationship between germ aversion and chronic pain remains unexplored.This study aimed to examine the relationship between germ aversi